Publications

2017

Journal Papers

Evaluation of the use of unipolar voltage amplitudes for detection of myocardial scar assessed by cardiac magnetic resonance imaging in heart failure patients
Nguyên UC, Maffessanti F, Mafi-Rad M, Conte G, Zeemering S, Regoli F, Caputo ML, van Stipdonk AMW, Bekkers S, Suerder D, Moccetti T, Krause R, Prinzen FW, Vernooy K, Auricchio A
PLOS One 2007 (in press)

Evaluation of a Rapid Anisotropic Model for ECG Simulation
Pezzuto S, Kal'avský P, Potse M, Prinzen FW, Auricchio A, Krause R
Front Physiol, 8:265, 2017 doi: 10.3389/fphys.2017.00265 Full text

Targeting bile acid receptors: discovery of a potent and selective Farnesoid X receptor agonist as a new lead in the pharmacological approach to liver diseases
Festa C, De Marino S, Carino A, Sepe V, Marchianò S, Cipriani S, Di Leva FS, Limongelli V, Monti MC, Capolupo A, Distrutti E, Fiorucci S, Zampella A
Frontiers in Pharmacology, 2017 (in press)

Unbinding kinetics of a p38 MAP kinase type II inhibitor from metadynamics simulations
Casasnovas R, Limongelli V, Pratyush T, Carloni P, Parrinello M
J Am Chem Soc 139:4780-4788, 2017 doi: 10.1021/jacs.6b12950

Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists
De Marino S, Carino A, Masullo D, Finamore C, Marchianò S, Di Leva FS, Novellino, Limongelli V, Fiorucci S, Zampella A
Sci Rep 7:43290, 2017 doi: 10.1038/srep43290

The relation between local repolarization and T-wave morphology in heart failure patients
Maffessanti F, Wanten J, Potse M, Regoli F, Caputo ML, Conte G, Sürder D, Illner A, Krause R, Moccetti T, Auricchio A, and Prinzen FW
International Journal of Cardiology, 2017 (in press) doi: 10.1016/j.ijcard.2017.02.056

Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations
Moraca F, Amato J, Ortuso F, Artese A, Pagano B, Novellino E, Alcaro S, Parrinello M, Limongelli V
Proc. Natl. Acad. Sci. USA, 2017 doi: 10.1073/pnas.1612627114

True idiopathic ventricular fibrillation in out-of-hospital cardiac arrest survivors in the Swiss Canton Ticino: prevalence, clinical features, and long-term follow-up
Conte G, Caputo ML, Regoli F, Marcon S, Klersy C, Adjibodou B, Del Bufalo A, Moccetti T, Auricchio A
Europace; 19(2):259-266 2017

Anatomic characterization of cavotricuspid isthmus by 3D transesophageal echocardiography in patients undergoing radiofrequency ablation of typical atrial flutter
Regoli F, Faletra F, Marcon S, Leo LA, Dequarti MC, Caputo ML, Conte G, Moccetti T, Auricchio A
Eur Heart J Cardiovasc Imaging. Feb 9. doi:10.1093/ehjci/jew336 2017 [Epub ahead of print]

Lay persons alerted by mobile application system initiate earlier cardio-pulmonary resuscitation: a comparison with SMS- based system notification
Caputo ML, Muschietti S, Burkart R, Benvenuti C, Conte G, Regoli F, Mauri R, Klersy C, Moccetti T, Auricchio A
Resuscitation; 114: 73-78, 2017

Temporal trends and long term follow-up of implantable cardioverter defibrillator therapy for secondary prevention: A 15-year single-centre experience
Caputo ML, Regoli F, Conte G, Adjibodou B, Svab S, Del Bufalo A, Moccetti T, Curti M, Klersy C, Auricchio A
Int J Cardiol; 228:31-36, 2017

Usefulness of P-Wave Duration and Morphologic Variability to Identify Patients Prone to Paroxysmal Atrial Fibrillation
Conte G, Luca A, Yazdani S, Caputo ML, Regoli F, Moccetti T, Kappenberger L, Vesin JM, Auricchio A
Am J Cardiol; 119(2): 275-279, 2017

Comparative performance assessment of commercially available automatic external defibrillators: A simulation and real-life measurement study of hands-off time
Savastano S, Vanni V, Burkart R, Raimondi M, Canevari F, Molinari S, Baldi E, Danza AI, Caputo ML, Mauri R, Regoli F, Conte G, Benvenuti C, Auricchio A
Resuscitation; 110:12-17, 2017

Inappropriate shocks in single-chamber and subcutaneous implantable cardioverter-defibrillators: a systematic review and meta-analysis
Auricchio A, Hudnall JH, Schloss EJ, Sterns LD, Kurita T, Meijer A, Fagan DH, Rogers T
Europace; Mar 10. doi: 10.1093/europace/euw415, 2017 [Epub ahead of print]

High rate of subcutaneous implantable cardioverter-defibrillator sensing screening failure in patients with Brugada syndrome: a comparison with other inherited primary arrhythmia syndromes
Conte G, Kawabata M, de Asmundis C, Taravelli E, Petracca F, Ruggiero D, Caputo ML, Regoli F, Chierchia GB, Chiodini A, Del Bufalo A, Moccetti T, Goya M, Hirao K, Vicentini A, De Ferrari GM, Brugada P, Auricchio A
Europace; Mar 7. doi: 10.1093/europace/eux009, 2017 [Epub ahead of print]

Catheter ablation of a left posterior fascicular ventricular tachycardia guided by a novel high-resolution multipolar mapping catheter
Conte G, Caputo ML, Regoli F, Moccetti T, Auricchio A
J Interv Card Electrophysiol; 49(1): 101-102, 2017

The European Lead Extraction ConTRolled (ELECTRa) study: a European Heart Rhythm Association (EHRA) Registry of Transvenous Lead Extraction Outcomes
Bongiorni MG, Kennergren C, Butter C, Deharo JC, Kutarski A, Rinaldi CA, Romano SL, Maggioni AP, Andarala M, Auricchio A, Kuck KH, Blomström-Lundqvist C; on behalf of ELECTRa Investigators
Eur Heart J. 2017 Mar 23. doi:10.1093/eurheartj/ehx080. [Epub ahead of print]

Potential Clinical Utility and Feasibility of Combined Left Atrial AppendageClosure and Positioning of Miniaturized Pacemaker Through a Single Right Femoral Vein Access
Regoli F, Araco M, Moccetti T, Caputo ML, Conte G, Auricchio A, Moccetti M
Am J Cardiol. 2017 Apr 27. pii: S0002-9149(17)30702-6.[Epub ahead of print]

Single freeze strategy with the second-generation cryballoon for atrial fibrillation: a multicenter international retrospective analysis in a large cohort of patients
De Regibus V, Iacopino S, Abugattas JP, Coutiño HE, Mugnai G, Storti C, Conte G, Auricchio A, Moran D, Ströker E, Marroquin L, Takarada K, Choudhury R, deAsmundis C, Brugada P, Chierchia GB
J Interv Card Electrophysiol. 2017 Jun 1. doi: 0.1007/s10840-017-0254-6. [Epub ahead of print]

Abstracts

Combined assessment of left ventricular electrical activation and myocardial strain mapping in heart failure patients
Maffessanti F, Prinzen FW, Conte G, Regoli FD, Caputo ML, Moccetti T, Faletra F, Krause R, and Auricchio A
In: Europace 19(suppl_3):iii317-iii317 EHRA EUROPACE 2017 Vienna, 18-21 June 2017.

Voltage distribution in patients with left bundle branch block: does location matter?
Maffessanti F, Nguyên U, Conte G, Regoli FD, Caputo ML, Faletra F, Moccetti T, Krause R, Prinzen FW, and Auricchio A.
In: Europace 19(suppl_3):iii317-iii318 EHRA EUROPACE 2017 Vienna, 18-21 June 2017.

Comparison between unipolar and bipolar voltage amplitude measurements for the detection of myocardial scar defined by delayed enhancement CMR: an endocardial electro-anatomic mapping study
Nguyên U, Maffessanti F, Jadczyk T, Conte G, Regoli F, Caputo ML, Suerder D, Golba K, Wilczekm J, Moccetti T, Krause R, Wojakowski W, Prinzen FW, and Auricchio A.
In: Europace 19(suppl_3):iii253-iii254  EHRA EUROPACE 2017 Vienna, 18-21 June 2017.

Endocardial and epicardial voltage amplitude measurements for myocardial scar detection: validation by delayed enhancement CMR in heart failure patients
Nguyên U, Maffessanti F, Zeemering, S, Conte G, Mafih-Rad M, Regoli F, Caputo ML, van Stipdonk AMW, Bekkers SCAM, Suerder D, Moccetti T, Krause R, Prinzen FW, Vernooy K, and Auricchio A.
In: Europace 19(suppl_3):iii34-iii34  EHRA EUROPACE 2017 Vienna, 18-21 June 2017.

Combined assessment of left ventricular electrical activation and myocardial strain mapping in heart failure patients
Maffessanti F, Prinzen FW, Conte G, Regoli FD, Caputo ML, Moccetti T, Faletra F, Krause R, and Auricchio A.
In: HRS 2017 Chicago, 10-13 May 2017.

Voltage distribution in patients with left bundle branch block: does location matter?
Maffessanti F, Nguyên U, Conte G, Regoli FD, Caputo ML, Faletra F, Moccetti T, Krause R, Prinzen FW, and Auricchio A.
In: HRS 2017 Chicago, 10-13 May 2017.

Head-to-head comparison of endocardial and epicardial voltage amplitudes with scar on delayed enhancement cardiac magnetic resonance imaging in heart failure patients
Nguyên U, Maffessanti F, Conte G, Regoli F, Caputo ML, Suerder D, Moccetti M, Krause R, Prinzen FW, and Auricchio A.
In: HRS 2017 Chicago, 10-13 May 2017.

Awards

Most meritorious runner-up of the 2017 EFMC (European Federation of Medicinal Chemistry) Prize
Prof. Vittorio Limongelli
In: EFMC-ASMC’17, Vienna, Austria, 27-31 August, 2017

2016

Journal Papers

Changes in P-wave morphology after pulmonary vein isolation: insights from computer simulations
M. Saha, G. Conte, M.L. Caputo, F. Regoli, R. Krause, A. Auricchio, and V. Jacquemet
Europace, 18(suppl 4):iv23-iv34, 2016 doi: 10.1093/europace/euw348

Impact of mechanical deformation on pseudoelectrocardiograms: a simulation study
M. Favino, S. Pozzi, S. Pezzuto, F.W. Prinzen, A. Auricchio, and R. Krause
Europace, 18(suppl 4):iv77-iv84, 2016 doi: 10.1093/europace/euw353

Conformational changes in the epidermal growth factor receptor: role of the transmembrane domain investigated by Coarse-Grained metadynamics free energy calculations
M. Lelimousin, Vittorio Limongelli, and M.S.P. Sansom.
J Am Chem Soc, 138:10611-22, 2016 doi: 10.1021/jacs.6b05602

Comprehensive 3D TTE evaluation of right and left heart chambers remodeling following percutaneous mitral valve repair
Paola Gripari, Gloria Tamborini, Vera Bottari, Francesco Maffessanti, Maria Chiara Carminati, Manuela Muratori, Carlo Vignati, Antonio L. Bartorelli, Francesco Alamanni, and Mauro Pepi.
J Am Soc Echocardiogr, 29(10):946-54, 2016 doi:10.1016/j.echo.2016.06.009

Reduced sodium current in the lateral ventricular wall induces inferolateral J-waves
Veronique M. F. Meijborg, Mark Potse, Chantal E. Conrath, Charly N. W. Belterman, Jacques M. T. de Bakker, and Ruben Coronel.
Front Physiol, 7:365, 2016 doi:10.3389/fphys.2016.00365

Spatially Coherent Activation Maps for Electrocardiographic Imaging
Josselin Duchateau, Mark Potse, and Rémi Dubois
IEEE Trans Biomed Eng, 2016. (Epub ahead of print) doi:10.1109/TBME.2016.2593003

The free energy landscape of GABA binding to a pentameric ligand-gated ion channel and its disruption by mutations
Comitani F, Limongelli V, and Molteni C.
J. Chem. Theory Compute, 12(7):3398–406, 2016 doi:10.1021/acs.jctc.6b00303

Segmentation of the left ventricular endocardium from magnetic resonance images by using different statistical shape models
Concetta Piazzese, M. Chiara Carminati, Andrea Colombo, Rolf Krause, Mark Potse, Angelo Auricchio, Lynn Weinert, Gloria Tamborini, Mauro Pepi, Roberto M. Lang, and Enrico G. Caiani.
J. Electrocardiol., 49:383-391, 2016. doi:10.1016/j.jelectrocard.2016.03.017

Ascending Aortic dimensions in hypertensive subjects: reference values for two-dimensional echocardiography
Enrico Vizzardi, Francesco Maffessanti, Roberto Lorusso, Sciatti Edoardo, Ivano Bonadei, Sandro Gelsomino, Marco Metra, and Mauro Pepi.
J Am Soc Echocardiogr, 29(9):827-37, 2016 doi: 10.1016/j.echo.2016.03.016

Enabling local time stepping in the parallel implicit solution of reaction–diffusion equations via space-time finite elements on shallow tree meshes
D. Krause and R. Krause.
Appl. Math. Comput. 277:164-179, 2016. doi:10.1016/j.amc.2015.12.017

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm
A. Muszkiewicz, O.J. Britton, P. Gemmell, E. Passini, C. Sánchez, X. Zhou, A. Carusi, T. A. Quinn, K. Burrage, A. Bueno-Orovio, and B. Rodriguez.
Prog. Biophys. Mol. Biol.,120(1-3):115-27, 2016 doi:10.1016/j.pbiomolbio.2015.12.002

Space-discretization error analysis and stabilization schemes for conduction velocity in cardiac electrophysiology
Simone Pezzuto, Johan Hake, Joakim Sundnes
Int. J. Numer. Method. Biomed. Eng., 32(10), 2016. doi:10.1002/cnm.2762

How disruption of endo-epicardial electrical connections enhances endo-epicardial conduction during atrial fibrillation
Ali Gharaviri, Sander Verheule, Jens Eckstein, Mark Potse, Pawel Kuklik, Nico H. L. Kuijpers, Ulrich Schotten.
Europace, euv 445, 2016 doi:10.1093/europace/euv445

Better management of out-of-hospital cardiac arrest increases survival rate and improves neurological outcome in the Swiss Canton Ticino
Mauri R, Burkart R, Benvenuti C, Caputo ML, Moccetti T, Del Bufalo A, Gallino A, Casso C, Anselmi L, Cassina T, Klersy C, Auricchio A
Europace; 18:398-404, 2016

Subcutaneous implantablecardioverter-defibrillator and drug-induced Brugada syndrome: the importance ofrepeat morphology analysis during ajmaline challenge
Conte G, Regoli F, Moccetti T, Auricchio A
Eur Heart J; 37:1498, 2016

Regoli F, Moccetti T, Pasotti E, Auricchio A, Moccetti M: Combined left atrialappendage closure and pace-maker implant through a single right femoral veinaccess. Pacing Clin Electrophysiol; 39:900-2, 2016

Extended detection time to reduce shocks is safe in secondary prevention patients: the secondary prevention sub-study of painfree SST
Sterns LD, Meine M, Kurita T, Meijer A, Auricchio A, Ando K, Leng CT, Okumura K, Sapp JL, Brown ML, Lexcen DR, Gerritse B, Schloss EJ
Heart Rhythm; 13:1489-96, 2016

High recurrence of device-related adverse events following transvenous lead extraction procedure in patients with cardiac resynchronization devices
Regoli F, Bongiorni MG, Rordorf R, Santamaria M, Klersy C, Segreti L, De Regibus V, Moccetti T, Conte G, Caputo ML, Auricchio A
Eur J Heart Fail; 18 (10): 1270-1277, 2016

Brugada syndrome and the subcutaneous implantable cardioverter-defibrillator
Olde Nordkamp LR, Conte G, Rosenmöller BR, Warnaars JL, Tan HL, Caputo ML, Regoli F, Moccetti T, Auricchio A, Knops RE, Wilde AA
J Am Coll Cardiol; 68:665-6, 2016

Transcatheter interatrial shunt device for the treatment of heart failure: rationale and design of the randomized trial to reduce elevated left atrial pressure in heart failure (REDUCE LAP-HF I)
Feldman T, Komtebedde J, Burkhoff D, Massaro J, Maurer MS, Leon MB, Kaye D, Silvestry FE, Cleland JG, Kitzman D, Kubo SH, Van Veldhuisen DJ, Kleber F, Trochu JN, Auricchio A, Gustafsson F, Hasenfuβ G, Ponikowski P, Filippatos G, Mauri L, Shah SJ
Circ Heart Fail; 9(7), 2016

Reducing ventricular pacing frequency in patients with atrioventricular block: is it time to change the current pacing paradigm?
Auricchio A, Ellenbogen KA
Circ Arrhythm Electrophysiol; 9(9), 2016

Brugada syndrome and early repolarisation: distinct clinical entities or different phenotypes of the same genetic disease?
Conte G, Caputo ML, Regoli F, Moccetti T, Brugada P, Auricchio A
Arrhythm Electrophysiol Rev; 5:84-9, 2016

Prevalence and clinical impact of early repolarization, pattern and QRS-fragmentation in high-risk patients with Brugada syndrome
Conte G, de Asmundis C, Sieira J, Ciconte G, Di Giovanni G, Chierchia GB, Casado-Arroyo R, Baltogiannis G, Ströker E, Irfan G, Pappaert G, Auricchio A, Brugada P
Circ J; 80(10): 2109-16, 2016

Cardiac MRI Anatomy and Function as a Substrate for Arrhythmias
Bucciarelli-Ducci C, Baritussi A, Auricchio A
Europace; 18 (suppl 4):iv130-iv135. doi: 10.1093/europace/euw357, 2016

Eighth TRM Forum on Computer Simulation and Experimental Assessment of Cardiac Function: Towards Integration of Cardiac Functions
Virag N, Jacquemet V, Kappenberger L, Auricchio A
Europace; 18(suppl 4):iv1-iv3. doi: 10.1093/europace/euw345, 2016

Pacing-Correctable Mitral Regurgitation: Something Old, Something New
Auricchio A
Circ Arrhythm Electrophysiol; 9(11), 2016

Reports

Research and Education in Computational Science and Engineering
Rüde U, Willcox K, McInnes LC, De Sterck H, Biros G, Bungartz H, Corones J, Cramer E, Crowley J, Ghattas O, Gunzburger M, Hanke M, Harrison R, Heroux M, Hesthaven J, Jimack P, Johnson C, Jordan KE, Keyes DE, Krause R, Kumar V, Mayer S, Meza J, Mørken KM, Oden JT, Petzold L, Raghavan P, Shontz SM, Trefethen A, Turner P, Voevodin V, Wohlmuth B, Woodward CS.
In: Report from a workshop sponsored by the Society for Industrial and Applied Mathematics (SIAM) and the European Exascale Software Initiative (EESI-2), August 4-6, 2014, Breckenridge, Colorado arXive page PDF

Abstracts

Accurate estimation of 3D ventricular activation from electroanatomic mapping
Pezzuto S, Kalavsky P, Potse M, Regoli F, Caputo ML, Conte G, Moccetti T, Prinzen FW, Auricchio A, Krause R.
In: EHRA EUROPACE 2016 Nice, 8-10 June 2016.

Assessment of left ventricular systolic function: head-to-head comparison between NOGA and MRI
Maffessanti F, Kroon W, Potse M, Prinzen FW, Regoli F, Murzilli R, Krause R, and Auricchio A.
In: HRS 2016 San Francisco, 4-7 May 2016.

Awards

Servier-SCT Award for the Young Researcher in Medicinal Chemistry 2016
Prof. Vittorio Limongelli
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Segmentation of the left ventricle combining information from short-axis and long-axis cardiac MR images into an inter-modality statistical shape modelling approach
Concetta Piazzese, Chiara M Carminati, Rolf Krause, Angelo Auricchio, Gloria Tamborini, Mauro Pepi, Roberto M Lang, Enrico G Caiani.
In: 12th IEEE EMBS International Summer School on Biomedical Imaging , Saint-Jacut de la Mer, Emerald Coast, Brittany, France, 16-24 June, 2016

2015

Journal Papers

Verification of cardiac mechanics software: benchmark problems and solutions for testing active and passive material behaviour
Sander Land, Viatcheslav Gurev, Sander Arens, Christoph M Augustin, Lukas Baron, Robert Blake, Chris Bradley, Sebastian Castro, Andrew Crozier, Marco Favino, Thomas E Fastl, Thomas Fritz, Hao Gao, Alessio Gizzi, Boyce E Griffith, Daniel E Hurtado, Rolf Krause, Xiaoyu Luo, Martyn P Nash, Simone Pezzuto, Gernot Plank, Simone Rossi, Daniel Ruprecht, Gunnar Seemann, Nicolas P Smith, Joakim Sundnes, J Jeremy Rice, Natalia Trayanova, Dafang Wang, Zhinuo Jenny Wang, Steven A Niederer.
Proc. R. Soc. A, 471(2184), Dec. 2015. doi:10.1098/rspa.2015.0641

High-order finite element methods for cardiac monodomain simulations
Kevin P Vincent, Matthew J Gonzales, Andrew K Gillette, Christopher T Villongco, Simone Pezzuto, Jeffrey H Omens, Michael J Holst, Andrew D McCulloch.
Front Physiol.6(217), 2015. doi:10.3389/fphys.2015.00217

Towards a large-scale scalable adaptive heart model using shallow tree meshes
Dorian Krause, Thomas Dickopf, Mark Potse, Rolf Krause.
J. Comp. Phys., 298:79-94, 2015. doi:10.1016/j.jcp.2015.05.005

An in-silico analysis of the effect of heart position and orientation on the ECG morphology and vectorcardiogram parameters in patients with heart failure and intraventricular conduction defects
Uyên Châu Nguyên, Mark Potse, François Regoli, Maria Luce Caputo, Giulio Conte, Romina Murzilli, Stefano Muzzarelli, Tiziano Moccetti, Frits W. Prinzen, Rolf Krause, and Angelo Auricchio.
J. Electrocardiol., 48:617-625, 2015. doi:10.1016/j.jelectrocard.2015.05.004

In-vivo Electromechanical Assessment of Heart Failure Patients with Prolonged QRS Duration
Wilco Kroon, Joost Lumens, Mark Potse, Daniel Suerder, Catherine Klersy, Francois Regoli, Romina Murzilli, Tiziano Moccetti, Tammo Delhaas, Rolf Krause, Frits W. Prinzen, and Angelo Auricchio.
Heart Rhythm, 6:1259-1267, 2015. doi:10.1016/j.hrthm.2015.03.006

Computer Modelling for Better Diagnosis and Therapy of Patients by Cardiac Resynchronisation Therapy
Marieke Pluijmert, Joost Lumens, Mark Potse, Tammo Delhaas, Angelo Auricchio, and Frits W. Prinzen.
Arrhythmia and Electrophysiology Review 4:62-67, 2015.

European Cardiac Resynchronization Therapy Survey II: rationale and design
Dickstein K, Normand C, Anker SD, Auricchio A, Lundqvist CB, Bogale N, Cleland J, Filippatos G, Gasparini M, Gitt A, Hindricks G, Kuck KH, Ponikowski P, Stellbrink C, Ruschitzka F, Linde C
Europace; 17:137-141, 2015

Clinical utility of routine use of continuous transesophageal echocardiography monitoring during transvenous lead extraction procedure
Regoli F, Caputo M, Conte G, Faletra FF, Moccetti T, Pasotti E, Cassina T, Casso G, Schlotterbeck H, Engeler A, Auricchio A
Heart Rhythm; 12:313-320, 2015

Low inappropriate shock rates in patients with single and dual/triple chamber ICDs using a novel suite of detection algorithms: PainFree SST Trial Primary Results
Auricchio A, Schloss EJ, Kurita T, Meijer A, Gerritse B, Zweibel S, AlSmadi FM, Leng CT, Sterns LD. On behalf of the PainFree SST Investigators
Heart Rhythm; 12:926-36, 2015

Comparison of clinical and angiographic prognostic risk scores in elderly patients presenting with acute coronary syndrome and referred for percutaneous coronary intervention
Vassalli G, d'Angeli I, Scherff F, Sürder D, Mantovani A, Pasotti E, Klersy C, Auricchio A, Moccetti T, Pedrazzini GB
Swiss Med Wkly; 6;145:w14, 2015

Validation of a simple risk stratificationtool for patients implanted with Cardiac Resynchronization Therapy: the VALID-CRTrisk score
Gasparini M, Klersy C, Leclercq C, Lunati M, Landolina M, Auricchio A, Santini M, Boriani G, Proclemer A, Leyva F
Eur J Heart Fail. 2015;17:717-24

Conference Proceedings

Three-dimensional echocardiography based evaluation of right ventricular remodeling in patients with pressure overload
Francesco Maffessanti, Karima Addetia, Megan Yamat, Lynn Weinert, Roberto Lang, Victor Mor-Avi.
In: Computing in Cardiology. September 2015.

Evaluation of different statistical shape models for segmentation of the left ventricular endocardium from magnetic resonance images
Concetta Piazzese, Maria C. Carminati, Rolf Krause, Mark Potse, Gloria Tamborini, Mauro Pepi, and Enrico G. Caiani.
In: Computing in Cardiology. September 2015.

Effect of the torso conductivity heterogeneities on the ECGI inverse problem solution
Nejib Zemzemi, Laura Bear, Remi Dubois, Corentin Dallet, Mark Potse, and Josselin Duchateau.
In: Computing in Cardiology. September 2015.

Abstracts

Multiscale sensitivity analysis in patient-specific models of cardiac electrophysiology
Carlos Sánchez, Mark Potse, François Regoli, Maria Luce Caputo, Giulio Conte, Tiziano Moccetti, Enrico G. Caiani, Frits W. Prinzen, Rolf Krause, and Angelo Auricchio.
In: EHRA EUROPACE - CARDIOSTIM. Milan, June 2015.

Effect of stem cell therapy on electrical and mechanical activation in heart failure patients
Francesco Maffessanti, Daniel Suerder, Wilco Kroon, Mark Potse, François Regoli, Romina Murzilli, Tiziano Moccetti, Frits W. Prinzen, Rolf Krause, and Angelo Auricchio.
In: EHRA EUROPACE - CARDIOSTIM. Milan, June 2015.

Electromechanical coupling in heart failure patients
Francesco Maffessanti, Wilco Kroon, Mark Potse, François Regoli, Romina Murzilli, Daniel Suerder, Tiziano Moccetti, Frits W. Prinzen, Rolf Krause, and Angelo Auricchio.
In: EHRA EUROPACE - CARDIOSTIM. Milan, June 2015.

Parameter sensitivity of multiscale patient-tailored heart models
Carlos Sánchez, Mark Potse, François Regoli, Maria Luce Caputo, Giulio Conte, Tiziano Moccetti, Enrico G. Caiani, Frits W. Prinzen, Rolf Krause, and Angelo Auricchio.
In: Joint Annual Meeting SSC/SSCC. Zürich, June 2015.

The influence of heart position and orientation on the 12-lead ecg in patients with heart failure and intraventricular conduction disturbances: a simulation study
Uyen Chau Nguyen, Mark Potse, François Regoli, Maria Luce Caputo, Giulio Conte, Romina Murzilli, Stefano Muzzarelli, Tiziano Moccetti, Frits W. Prinzen, Rolf Krause, and Angelo Auricchio.
In: Joint Annual Meeting SSC/SSCC. Zürich, June 2015.

New insights into electromechanics in heart failure patients
Francesco Maffessanti, Wilco Kroon, Mark Potse, François Regoli, Romina Murzilli, Daniel Suerder, Tiziano Moccetti, Frits W. Prinzen, Rolf Krause, and Angelo Auricchio.
In: Joint Annual Meeting SSC/SSCC. Zürich, June 2015.

2014

Journal Papers

Seventh Theo Rossi di Montelera Forum on Computer Simulation and Experimental Assessment of Cardiac Function: Creating the Basis for Tailored Therapies
Natalie Virag, Vincent Jacquemet, Lukas Kappenberger, and Angelo Auricchio.
Europace, 16(Supplement 4) :iv1-iv2, 2014. doi: 10.1093/europace/euu253

Patient-specific modelling of cardiac electrophysiology in heart-failure patients
Mark Potse, Dorian Krause, Wilco Kroon, Romina Murzilli, Stefano Muzzarelli, François Regoli, Enrico G. Caiani, Frits W. Prinzen, Rolf Krause, and Angelo Auricchio.
Europace, 16(Supplement 4) :iv56-iv61, 2014. doi: 10.1093/europace/euu257

3D Left ventricular segmentation from MRI images for patient-specific modeling purposes
Enrico G. Caiani, Andrea Colombo, Mauro Pepi, Concetta Piazzese, Francesco Maffessanti, Roberto M. Lang, and Maria C. Carminati.
Europace, 16(Supplement 4) :iv96-iv101, 2014. doi: 10.1093/europace/euu232

Semi-automated detection and quantification of aortic atheromas from three-dimensional transesophageal echocardiography
Concetta Piazzese, Wendy Tsang, Miguel Sotaquira, Itzhak Kronzon, Roberto M. Lang, and Enrico G. Caiani.
JASE, 27(7):758-66, 2014. doi: 10.1016/j.echo.2014.03.003

Design and analysis of a lightweight parallel adaptive scheme for the solution of the monodomain equation
Thomas Dickopf, Dorian Krause, Rolf Krause, and Mark Potse.
SIAM J Sci Comp, 36(2) :C163-C189, 2014. doi: 10.1137/130912505

Absolute survival after cardiac resynchronization therapy according to baseline QRS duration: A multinational 10-year experience: Data from the Multicenter International CRT Study
Gasparini M, Leclercq C, Yu CM, Auricchio A, Steinberg JS, Lamp B, Klersy C, Leyva F
Am Heart J; 167:203-209, 2014

Electrophysiological and haemodynamic effects of vernakalant and flecainide in dyssynchronous canine hearts
van Middendorp LB, Strik M, Houthuizen P, Kuiper M, Maessen JG, Auricchio A, Prinzen FW
Europace; 16:1249-1256, 2014

Feasibility, safety, and short-term outcome of leadless ultrasound-based endocardial left ventricular resynchronization in heart failure patients: results of the Wireless Stimulation Endocardially for CRT (WiSE-CRT) study
Auricchio A, Delnoy PP, Butter C, Brachmann J, Van Erven L, Spitzer S, Moccetti T, Seifert M, Markou T, Laszo K, Regoli F for the Collaborative Study Group
Europace; 16:681-688, 2014

Personality traits, cardiac risk factors, and their association with presence and severity of coronary artery plaque in people with no history of cardiovascular disease
Compare A, Mommersteeg PM, Faletra F, Grossi E, Pasotti E, Moccetti T, Auricchio A
J Cardiovasc Med (Hagerstown); 15:423-430, 2014

Long-term effectiveness of the combined minute ventilation and patient activity sensors as predictor of heart failure events in patients treated with cardiac resynchronization therapy: Results of the Clinical Evaluation of the Physiological Diagnosis Function in the PARADYM CRT device Trial (CLEPSYDRA) study
Auricchio A, Gold MR, Brugada J, Nölker G, Arunasalam S, Leclercq C, Defaye P, Calò L, Baumann O, Leyva F
Eur J Heart Fail; 16:663-670, 2014

Statistics on the use of cardiac electronic devices and electrophysiological procedures in 55 ESC countries: 2013 report from the European Heart Rhythm Association (EHRA)
Arribas F, Auricchio A, Boriani G, Brugada J, Deharo JC, Hindriks G, Kuck KH, Merino JL, Vardas P, Wolpert C, Zeppenfeld K
Europace; 16:i1-i78, 2014

2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy
TheTask Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA), Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, Cleland J, Deharo JC, Delgado V, Elliott PM, Gorenek B, Israel CW, Leclercq C, Linde C, Mont L, Padeletti L, Sutton R, Vardas PE
Rev Esp Cardiol (Engl Ed); 67:58, 2014

Does cardiac resynchronization therapy benefit patients with right bundle branch block: cardiac resynchronization therapy has a role in patients with right bundle branch block
Auricchio A, Lumens J, Prinzen FW
Circ Arrhythm Electrophysiol; 7:532-542, 2014

3D real-time TEE during pulmonary vein isolation in atrial fibrillation
Acena M, Regoli F, Faletra FF, Tritto M, Klersy C, Murzilli R, Scopigni F, Penco M, Pasotti E, Moccetti T, Auricchio A
JACC Cardiovasc Imaging; 7:737-738, 2014

20 Years of Cardiac Resynchronization Therapy
Leyva F, Nisam S, Auricchio A:
J Am Coll Cardiol; 9:1047-1058, 2014

Seventh TRM Forum on Computer Simulation and Experimental Assessment of Cardiac Function: Creating the Basis for Tailored Therapies
Virag N, Jacquemet V, Kappenberger L, Auricchio A
Europace; 4:iv1-iv2, 2014

Conference Proceedings

Localization of the Latest-Activated Areas in the Ventricles from Body Surface Potential Maps
Jana Svehlikova, Mark Potse, and Milan Tysler.
In: Computing in Cardiology. Cambridge (MA), September 2014; 41 :129-132. http://www.cinc.org/archives/2014/pdf/0129.pdf

Abstracts

Computer modeling to understand the failing heart
Mark Potse.
In: The 41st International Congress on Electrocardiology. Bratislava, June 2014.

The Lead Fields of the Standard 12-Lead ECG
Mark Potse.
In: The 41st International Congress on Electrocardiology. Bratislava, June 2014.

Awards

An in-silico analysis of the effect of heart position and orientation on the 12-lead ECG in a patient with left bundle branch block
Uyên Chau Nguyên, Mark Potse, Angelo Auricchio, Rolf Krause, and Frits W. Prinzen.
In: Twelfth meeting on iMaging And eLectrical Technologies, Noordwijk, the Netherlands, April 2014. Second in the Young Investigator Competition.

2013

Journal Papers

Real-time three dimensional transoesophageal echocardiography in imaging key anatomical structures of the left atrium: potential role during atrial fibrillation ablation
Faletra FF, Ho SY, Regoli F, Acena M, Auricchio A
Heart; 99:133-142, 2013

For the collaborative study group. Validation of Seattle Heart Failure Model for mortality risk prediction in patients treated with cardiac resynchronization therapy
Regoli F, Scopigni F, Leyva F, Landolina M, Ghio S, Tritto M, Calò L, Klersy C, Auricchio A
Eur J Heart Fail; 15:211-220, 2013

Health technology assessment in interventional electrophysiology and device therapy: a position paper of the European Heart Rhythm Association
Boriani G, Maniadakis N, Auricchio A, Müller-Riemenschneider F, Fattore G, Leyva F, Mantovani L, Siebert M, Willich SN, Vardas P, Kirchhof P
Eur Heart J; 34:1869-1874, 2013

First-in-man implantation of leadless ultrasound-based cardiac stimulation pacing system: novel endocardial left ventricular resynchronization therapy in heart failure patients
Auricchio A, Delnoy PP, Regoli F, Seifert M, Markou T, Butter C: collaborative study group
Europace; 15:1191-1197, 2013

Combined Delivery of Bone Marrow-Derived Mononuclear Cells in Chronic Ischemic Heart Disease: Rationale and Study Design
Sürder D, Radrizzani M, Turchetto L, Cicero VL, Soncin S, Muzzarelli S, Auricchio A, Moccetti T
Clin Cardiol; 36:435-441, 201

Adrenergic receptor gene polymorphism and left ventricular reverse remodelling after cardiac resynchronization therapy: preliminary results
Pezzali N, Curnis A, Specchia C, Carubelli V, Covolo L, Donato F, Auricchio A, Regoli F, Metra M
Europace; 15:1475-1481

The use of imaging for electrophysiological and devices procedures: a report from the first European Heart Rhythm Association Policy Conference, jointly organized with the European Association of Cardiovascular Imaging (EACVI), the Council of Cardiovascular Imaging and the European Society of Cardiac Radiology
Blomström Lundqvist C, Auricchio A, Brugada J, Boriani G, Bremerich J, Cabrera JA, Frank H, Gutberlet M, Heidbuchel H, Kuck KH, Lancellotti P, Rademakers F, Winkels G, Wolpert C, Vardas PE
Europace; 15:927-936

Recommendations for post-implant monitoring of patients with cardiovascular implantable electronic devices: where do we stand today?
Varma N, Auricchio A
Europace; 15(Suppl 1):i11-i13, 2013

2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: The Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA)
Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, Cleland J, Deharo JC, Delgado V, Elliott PM, Gorenek B, Israel CW, Leclercq C, Linde C, Mont L, Padeletti L, Sutton R, Vardas PE; ESC Committee for Practice Guidelines (CPG), Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S; Document Reviewers, Kirchhof P, Blomstrom-Lundqvist C, Badano LP, Aliyev F, Bänsch D, Baumgartner H, Bsata W, Buser P, Charron P, Daubert JC, Dobreanu D, Faerestrand S, Hasdai D, Hoes AW, Le Heuzey JY, Mavrakis H, McDonagh T, Merino JL, Nawar MM, Nielsen JC, Pieske B, Poposka L, Ruschitzka F, Tendera M, Van Gelder IC, Wilson CM
Eur Heart J; 34:2281-2329, 2013

2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: The Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA)
Brignole M, Auricchio A, Baron-Esquivias G,Bordachar P, Boriani G, Breithardt OA, Cleland J, Deharo JC, Delgado V, Elliott PM, Gorenek B, Israel CW, Leclercq C, Linde C, Mont L, Padeletti L, Sutton R, Vardas PE; ESC Committee for Practice Guidelines (CPG), Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S; Document Reviewers, Kirchhof P, Blomstrom-Lundqvist C, Badano LP, Aliyev F, Bänsch D, Baumgartner H, Bsata W, Buser P, Charron P, Daubert JC, Dobreanu D, Faerestrand S, Hasdai D, Hoes AW, Le Heuzey JY, Mavrakis H, McDonagh T, Merino JL, Nawar MM, Nielsen JC, Pieske B, Poposka L, Ruschitzka F, Tendera M, Van Gelder IC, Wilson CM
Europace; 15:1070-1118, 2013

Transseptal conduction as an important determinant for cardiac resynchronization therapy, as revealed by extensive electrical mapping in the dyssynchronous canine heart
Strik M, van Deursen CJ, van Middendorp LB, van Hunnik A, Kuiper M, Auricchio A, Prinzen FW
Circ Arrhythm Electrophysiol; 24:171-175, 2013

ELECTRa (European) Lead Extraction ConTRolled) Registry-Shedding light on transvenous lead extraction real-world practice in Europe
Bongiorni MG, Romano SL, Kennergren C, Butter C, Deharo JC, Kutarsky A, Rinaldi CA, Maggioni AP, Blomström-Lundqvist C, Auricchio A
Herzschrittmacherther Elektrophysiol; 24:171-175, 2013

U-shaped mechanical activation 4 u?
Prinzen FW, Kroon W, Auricchio A
JACC Cardiovasc Imaging; 6:874-876, 2013

Kirchhof P, Breithardt G, Aliot E, Khatib SA, Apostolakis S, Auricchio A, Bailleul C, Bax J, Benninger G, Blomstrom-Lundqvist C, Boersma L, Boriani G, Brandes A, Brown H, Brueckmann M, Calkins H, Casadei B, Clemens A, Crijns H, Derwand R, Dobrev D, Ezekowitz M, Fetsch T, Gerth A, Gillis A, Gulizia M, Hack G, Haegeli L, Hatem S, Georg Häusler K, Heidbüchel H, Hernandez-Brichis J, Jais P, Kappenberger L, Kautzner J, Kim S, Kuck KH, Lane D, Leute A, Lewalter T, Meyer R, Mont L, Moses G, Mueller M, Münzel F, Näbauer M, Nielsen JC, Oeff M, Oto A, Pieske B, Pisters R, Potpara T, Rasmussen L, Ravens U, Reiffel J, Richard-Lordereau I, Schäfer H, Schotten U, Stegink W, Stein K, Steinbeck G, Szumowski L, Tavazzi L, Themistoclakis S, Thomitzek K, Van Gelder IC, von Stritzky B, Vincent A, Werring D, Willems S, Lip GY, Camm AJ: Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference. Europace; 15:1540-1556, 2013

Strik M, van Middendorp LB, Houthuizen P, Ploux S, van Hunnik A, Kuiper M, Auricchio A, Prinzen FW: The interplay of electrical wave fronts as determinant of the response to cardiac resynchronization therapy in dyssynchronous canine hearts. Circ Arrhythm Electrophysiol; 6:924-931, 2013

Compare A, Grossi E, Buscema M, Zarbo C, Mao X, Faletra F, Pasotti E, Moccetti T, Mommersteeg PM, Auricchio A: Combining personality traits with traditional risk factors for coronary stenosis: an artificial neural networks solution in patients with computed tomography detected coronary artery disease. Cardiovasc Psychiatry Neurol; 10:1155/2013/814967, 2013

Cardiac Resynchronization Therapy in Patients With Atrial Fibrillation: The CERTIFY Study (Cardiac Resynchronization Therapy in Atrial Fibrillation Patients Multinational Registry)
Gasparini M, Leclercq C, Lunati M, Landolina M, Auricchio A, Santini M, Boriani G, Lamp B, Proclemer A, Curnis A, Klersy C, Leyva F
JACC Heart Fail; 1:500-507, 2013

Cardiac Resynchronization Therapy:State-of-the-Art of Current Applications, Guidelines, Ongoing Trials, and Areas of Controversy
Prinzen FW, Vernooy K, Auricchio A
Circulation; 28:2407-2418, 2013

Mechanical Dyssynchrony Precedes QRS Widening in ATP-Sensitive K+Channel-Deficient Dilated Cardiomyopathy
Yamada S, Arrell DK, Kane GC, Nelson TJ, Perez-Terzic CM, Behfar A, Purushothaman S, Prinzen FW, Auricchio A, Terzic A
J Am Heart Assoc; 5:2, 2013

Conference Proceedings

Evaluation of the relation between changes in R-wave amplitude and LV mass and dimensions in a model of "reversed hypertrophy"
Enrico G. Caiani, Angelo Auricchio, Mark Potse, Rolf Krause, Alessandro Pellegrini, Robert M. Lang, and Pierre Vaida.
In: Computing in Cardiology. Zaragoza, September 2013; 40 :867-870. http://www.cinc.org/archives/2013/pdf/0867.pdf

Abstracts

Heterogeneity in electromechanical delay in heart-failure patients referred for CRT
Wilco Kroon, Mark Potse, Rolf Krause, Hanspeter Fischer, François Regoli, Marta Acena, Frits W. Prinzen, and Angelo Auricchio.
In: EHRA Europace congress. Athens, June 2013.

Patient-specific computer modeling for analysis of ventricular conduction disorders
Mark Potse, Wilco Kroon, Dorian Krause, Marta Acena, François Regoli, Romina Murzilli, Enrico G. Caiani, Frits W. Prinzen, Rolf Krause, and Angelo Auricchio.
In: EHRA Europace congress. Athens, June 2013.

Reconstruction of catheter electrograms and 12-lead ECG in heart-failure patients using a bidomain reaction-diffusion model of the heart and torso
Mark Potse.
In: SIAM Conference on Computational Science and Engineering. Boston, February 2013.

Portability of a large-scale heart model through hybrid parallelization
Thomas Dickopf, Dorian Krause, Mark Potse, and Rolf Krause.
In: SIAM Conference on Computational Science and Engineering. Boston, February 2013.

PhD Theses

Derivation, simulation and validation of poroelastic models in dental biomechanics
Dorian Krause.
In: Università della Svizzera italiana, Lugano, October 14th 2013.

2012

Journal Papers

Similarities and differences between ECG signs of left bundle branch block and left-ventricular uncoupling
Mark Potse, Dorian Krause, Ljuba Bacharova, Rolf Krause, Frits W. Prinzen, and Angelo Auricchio.
Europace, 14(Supplement 5) :v33-v39, 2012. doi: 10.1093/europace/eus272

Computer simulation of ECG manifestations of left ventricular electrical remodeling
Ljuba Bacharova, Vavrinec Szathmary, Mark Potse, and Anton Mateasik.
J Electrocardiol, 5 :146-158, 2012. doi: 10.1016/j.jelectrocard.2012.07.009

Mathematical modeling and simulation of ventricular activation sequences: implications for cardiac resynchronization therapy
Mark Potse.
J Cardiovasc Transl Res, 45 :630-634, 2012. doi: 10.1007/s12265-011-9343-6

Abstracts

Large-scale parallel mono- and bidomain solvers in a realistic heart model
Thomas Dickopf, Dorian Krause, Mark Potse, and Rolf Krause.
In: World Congress on Computational Mechanics. São Paulo, July 2012.

Towards model-based assessment of myocardial substrate for planning cardiac resynchronisation therapy
Wilco Kroon, Mark Potse, Angelo Auricchio, Tammo Delhaas, Frits W. Prinzen, and Rolf Krause.
In: World Congress on Computational Mechanics. São Paulo, July 2012.

Scalable solvers for electrocardiology on massively parallel architectures
Dorian Krause, Mark Potse, Thomas Dickopf, and Rolf Krause.
In: 21st International Conference on Domain Decomposition Methods. Rennes, June 2012.

2011

Journal Papers

The effect of reduced intercellular coupling on electrocardiographic signs of left ventricular hypertrophy
Ljuba Bacharova, Anton Mateasik, Rolf Krause, Frits W. Prinzen, Angelo Auricchio, and Mark Potse.
J Electrocardiol, 44 :571-576, 2011. doi: 10.1016/j.jelectrocard.2011.06.004

Conference Proceedings

Hybrid Parallelization of a Large-Scale Heart Model
Dorian Krause, Mark Potse, Thomas Dickopf, Rolf Krause, Angelo Auricchio, and Frits W. Prinzen.
In: Facing the Multicore Challenge II. October 2011. doi: 10.1007/978-3-642-30397-5_11

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